Nedocromil is an asthma medication that possesses potent cromolyn-like anti-inflammatory properties. In asthmatics, it is able to prevent bronchospasm from allergic and non-allergic triggers including sulfites, exercise and cold air.
When inhaled regularly, it also decreases bronchial hyperreactivity and improves lung function. It is highly effective in reducing asthmatic cough.
Nedocromil acts on mast cells and other inflammatory cells, inactivating them and preventing release of inflammatory mediators. It may also prevent activation of sensory nerve endings in the lining of the bronchial tubes helping reduce cough and reflex bronchospasm seen in asthma. Onset of action is as early as a few days though peak effects may not be seen for many weeks.
Transient unpleasant bitter taste is experienced by a minority of patients. No toxicities or drug interactions are known.
Nedocromil is currently available only as a metered dose inhaler. The usual dose is 2 puffs (4 mg) four times daily although it is sometimes given at 4 puffs twice daily. After adequate control is achieved, it can often be tapered to 2 puffs twice daily.
- When taste is a problem, improved inhaler technique and/or a good spacer will often help. A flavored drink, candy or mouthwash before and/or after inhalation can reduce the taste.
- Occasionally, in patients already on inhaled corticosteroids, the addition of Tilade may improve symptom control.
- Tilade is not recommended for children under the age of 12.